•Etoricoxib is used to relieve inflammation and pain in the following conditions:
• Osteoarthritis.
• Rheumatoid arthritis.
• A form of arthritis affecting the joints of the spine (ankylosing spondylitis).
• Acute gout.
• Moderate pain associated with dental surgery.

• Etoricoxib tablets should be taken once a day. The dose prescribed depends on the condition being treated. Follow the instructions given by your doctor.
• Etoricoxib tablets can be taken either with or without food, but they may start to work to relieve pain quicker if they are taken without food.
• The tablets usually need to be taken every day on a regular basis to reduce inflammation and pain in arthritis. However, they should not be taken for longer than eight days to relieve acute pain associated with gout. They should not be taken for longer than three days to relieve pain following dental surgery.
• If you forget to take a tablet don't worry, just leave out that dose and take your next dose as usual. Do not take a double dose to make up for a missed dose.
• Never take more than the dose prescribed by your doctor. If you think this medicine is not working well enough you should make an appointment with your doctor.

• This medicine may cause fatigue and dizziness. You should take care when performing potentially hazardous activites, such as driving or operating machinery, until you know how this medicine affects you and are sure you can perform such activities safely.
• NSAIDs, including COX-2 inhibitors such as this one, can occasionally cause serious side effects on the gut, such as ulceration, bleeding or perforation of the stomach or intestinal lining. This type of side effect is more likely to occur in elderly people and in people taking high doses of the medicine. The risk can also be increased by taking certain other medicines (see end of factsheet). It is important that these people, as well as people with a history of disorders affecting the stomach or intestines, are closely monitored by a doctor while taking this medicine. All people taking this medicine should stop treatment and consult their doctor immediately if they experience any sign of bleeding from the stomach or intestine during treatment, for example vomiting blood and/or passing black/tarry/bloodstained stools.
• COX-2 inhibitors may carry an increased risk of heart attacks and stroke when compared to placebo (no treatment). If you have risk factors for heart disease or stroke, such as diabetes, high cholesterol or smoking, your doctor will need to assess the overall benefits and risks before deciding if this medicine is suitable for you. In general, if this medicine is suitable, your doctor will prescribe the lowest effective dose for as short a time as possible to control your symptoms, because the risks may increase with higher doses and the longer the medicine is taken. Do not exceed the prescribed dose. Tell your doctor if you experience shortness of breath, chest pains or ankle swelling while taking the medicine. Ask your doctor or pharmacist for further information.
• Your blood pressure should be regularly monitored while you are taking this medicine, particularly in the first two weeks after starting treatment.
• If you have any problems with your kidneys, liver or heart function, your kidney function should be regularly monitored while you are taking this medicine.
• During long-term treatment your doctor may want to take regular blood tests to monitor your liver function. Consult your doctor promptly if you develop unexplained itching, yellowing of the skin or eyes, unusually dark urine, nausea and vomiting, abdominal pains, loss of appetite or flu-like symptoms while taking this medicine, as they may be signs of a liver problem.
• This medicine may hide fever, which is a sign of infection. This may make you think mistakenly that an infection is getting better when it isn't, or that an infection is less serious than it is. For this reason you should tell your doctor if you get an infection while you are taking this medicine.
• Very rarely, NSAIDS may cause serious blistering or peeling skin reactions (eg Stevens-Johnson syndrome, toxic epidermal necrolysis, exfoliative dermatitis). For this reason, you should stop taking this medicine and consult your doctor if you get a skin rash or sores inside your mouth while taking this medicine. This side effect is very rare, but if it occurs, is most likely to happen in the first month of treatment.

• Elderly people.
• People with a history of disorders affecting the stomach or intestines, such as ulceration or bleeding.
• People with decreased kidney function.
• People with decreased liver function.
• Liver cirrhosis.
• Dehydration.
• People with any swelling due to excess fluid retention (oedema).
• People with a history of heart failure.
• People with high blood pressure (hypertension).
• People with raised levels of fats such as cholesterol in their blood (hyperlipidaemia).
• Diabetes.
• Smokers.
• People with a history of allergies to medicines.

• Children and adolescents under 16 years of age.
• People in whom aspirin or other NSAIDs, eg ibuprofen, cause allergic reactions such as asthma attacks, itchy rash (urticaria), nasal polyps, nasal inflammation (rhinitis) or swelling of the lips, tongue and throat (angioedema).
• People with severely decreased liver function.
• People with moderate to severely decreased kidney function.
• People with an active peptic ulcer or bleeding in the gut.
• Inflammatory bowel disease such as Crohn's disease or ulcerative colitis.
• Uncontrolled high blood pressure (hypertension).
• Heart failure.
• Heart disease caused by inadequate blood flow to the heart (ischaemic heart disease), eg angina or history of heart attack.
• Disease of the blood vessels in and around the brain (cerebrovascular disease), eg history of stroke.
• People with poor blood circulation in the arteries of the legs or feet (peripheral arterial disease).
• Pregnancy.
• Breastfeeding.
• Rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malsorption (Etoricoxiba tablets contain lactose). This medicine should not be used if you are allergic to one or any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy. If you feel you have experienced an allergic reaction, stop using this medicine and inform your doctor or pharmacist immediately

•Certain medicines should not be used during pregnancy or breastfeeding. However, other medicines may be safely used in pregnancy or breastfeeding providing the benefits to the mother outweigh the risks to the unborn baby. Always inform your doctor if you are pregnant or planning a pregnancy, before using any medicine.
• This medicine should not be used in pregnancy, particularly the third trimester, as it may delay labour, increase the length of labour and cause complications in the newborn baby. Some evidence suggests that NSAIDs should also be avoided by women attempting to conceive, as they may temporarily reduce female fertility during treatment and may also increase the risk of miscarriage or malformations. Seek further medical advice from your doctor.
• It is not known if this medicine passes into breast milk. Mothers who need to take this medicine should not breastfeed. Seek further medical advice from your doctor.

•Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Just because a side effect is stated here does not mean that all people using this medicine will experience that or any side effect.
• Excessive fluid retention in the body tissues, resulting in swelling (oedema).
• Dizziness.
• Headache.
• High blood pressure (hypertension).
• Awareness of your heartbeat (palpitations).
• Irregular heartbeat (arrhythmia).
• Disturbances of the gut such as diarrhoea, nausea, vomiting, heartburn, indigestion, flatulence or abdominal pain.
• Inflammation of the stomach (gastritis) or foodpipe (oesophagitis).
• Feeling weak or fatigued.
• Cold or flu-like symptoms.
• Wheezing or shortness of breath (bronchospasm).
• Bruising.
• Dry socket (alveolar osteitis).
• Mouth ulcers.
• Change in appetite, weight gain.
• Anxiety or depression.
• Decreased mental sharpness.
• Hallucinations.
• Difficulty sleeping (insomnia).
• Sleepiness.
• Dry mouth, change in taste.
• Changes in sensation, eg pins and needles or tingling sensations.
• Spinning sensation (vertigo).
• Sensation of ringing or other noise in the ears (tinnitus).
• Blurred vision.
• Eye inflammation (conjunctivitis).
• Nosebleeds.
• Cough or shortness of breath (dyspnoea).
• Skin reactions such as rash and itch.
• Muscle cramps or spasms.
• Flushing.
• Skin rash, hives, itching or redness.
• Swelling of the face.
• Chest pain (angina).
• Fast heartbeat (tachycardia).
• Heart failure, heart attack, stroke or mini-stroke (see warning section above for more information).
• Ulceration or bleeding in the stomach or intestine (see warning section above for more information).
• Irritable bowel syndrome.
• Inflammation of the pancreas (pancreatitis).
• Decreased numbers of white blood cells, red blood cells or platelets in the blood.
• Kidney failure.
• Inflammation of the liver (hepatitis), liver failure, jaundice (see warning section above).
• Severe skin reactions such as Stevens-Johnson syndrome, toxic epidermal necrolysis (see warning section above). The side effects listed above may not include all of the side effects reported by the medicine's manufacturer. For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist

•It is important to tell your doctor or pharmacist what medicines you are already taking, including those bought without a prescription and herbal medicines, before you start treatment with this medicine. Similarly, check with your doctor or pharmacist before taking any new medicines while taking this one, to make sure that the combination is safe. This medicine may be taken with low-dose (75mg daily) aspirin. However, the combination may carry an increased risk of ulceration or bleeding in the stomach or intestines compared to taking etoricoxib on its own. Etoricoxib should not be taken with higher daily doses of aspirin. For more information and advice ask your doctor or pharmacist. This medicine should not be taken with other non-steroidal anti-inflammatory drugs (NSAIDs), eg ibuprofen, diclofenac, naproxen, as using more than one NSAID together also increases the risk of side effects in the gut such as ulceration or bleeding. You should not take these types of painkiller while you are taking etoricoxib. This medicine may increase the anti-blood-clotting effect of warfarin. As this may increase the risk of bleeding, people taking warfarin with this medicine should have their blood-clotting time (INR) regularly monitored, particularly in the first few days of treatment with etoricoxib and following any dose changes. There may also be an increased risk of bleeding if this medicine is taken in combination with the following medicines:
• antiplatelet or 'blood thinning' medicines such as clopidogrel or dipyridamole.
• erlotinib
• heparins
• iloprost
• oral anticoagulants, such as apixaban, rivaroxaban or dabigatran
• prasugrel
• venlafaxine. This medicine may oppose the effect of diuretics and other medicines for high blood pressure (antihypertensives). There may be an increased risk of side effects on the kidneys if this medicine is taken with any of the following medicines. People taking any of these medicines in combination with etoricoxib should have their kidney function monitored, particularly if elderly:
• ACE inhibitors, eg enalapril, captopril
• angiotensin II antagonists, eg losartan
• ciclosporin
• diuretics such as furosemide
• tacrolimus. This medicine may increase the blood levels of the following medicines:
• digoxin
• lithium (your lithium blood level should be monitored if you are starting, changing dose, or stopping etoricoxib while taking lithium)
• methotrexate (people taking methotrexate should be monitored for any side effects of methotrexate while taking etoricoxib)
• oestrogens in oral contraceptives or HRT (this may increase the risk of side effects from these medicines; discuss this with your doctor). Rifampicin may decrease the blood level of this medicine and therefore make it less effective at treating pain.

•Read the package insert and/or patient product information sheet that comes with your prescription.
• Most medications should be stored in a dry place away from heat and humidity.
• Some medications also have special instructions for storage. Check for special instructions on your prescription label.
• If your medication needs to be protected from light, it should be stored in a container that filters out light, such as a clean film canister.
• If your medication needs to be refrigerated, and you do not have a fridge available (for example, if you are working outside or on the road all day), try using a cooler with an ice pack. An ordinary cooler found at hardware or sporting goods stores will do.

•Consult your doctor for further instructions and also read the package insert and/or patient product information sheet that comes with your prescription.

• Thiocolchicoside is used (as an additive treatment) for relieving painful stiffness or constriction in various diseases of the muscles, nerves, spine and the joints.

• Use as you have been told by the doctor.

• It is contraindicated during pregnancy.

• Avoid Alcohol.

• Do not take if you are allergic to thiocolchicoside.

•Category C : Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

•Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Just because a side effect is stated here, it does not mean that all people using this medicine will experience that or any side effect.
• Skin irritation, eg itching, burning, stinging.
• Thinning of the skin.
• Changes in skin pigmentation.
• Stretch marks (striae).
• Groupings of fine blood vessels becoming prominent under the skin (telangiectasia).
• Excessive hair growth (hypertrichosis). Prolonged use of this medicine on extensive areas of skin, broken or raw skin, skin folds or underneath airtight dressings may on rare occasions result in enough corticosteroid being absorbed to have side effects on other parts of the body, for example a decrease in the production of natural hormones by the adrenal glands - see warning section above. The side effects listed above may not include all of the side effects reported by the medicine's manufacturer. For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist.

•It is important to tell your doctor or pharmacist what medicines you are already taking, including those bought without a prescription and herbal medicines, before you start treatment with this medicine. Similarly, check with your doctor or pharmacist before taking any new medicines while being treated with this one, to make sure that the combination is safe. Abiraterone may increase the levels of the following medicines in the blood. If you are taking any of these your doctor may have to reduce your dosage:
• codeine
• desipramine
• flecainide
• haloperidol
• metoprolol
• propafenone
• propranolol
• risperidone
• oxycodone
• tramadol
• venlafaxine. The following medicines could affect the level of abiraterone in the blood and so should be avoided where possible while you are having treatment with this medicine:
• atazanavir
• azole antifungals such as ketoconazole, itraconazole
• carbamazepine
• clarithromycin
• indinavir
• nefazodone
• nelfinavir
• phenobarbital
• phenytoin
• rifabutin
• rifampicin
• rifapentine
• ritonavir
• saquinavir
• telithromycin
• voriconazole.

•Read the package insert and/or patient product information sheet that comes with your prescription.
• Most medications should be stored in a dry place away from heat and humidity.
• Some medications also have special instructions for storage. Check for special instructions on your prescription label.
• If your medication needs to be protected from light, it should be stored in a container that filters out light, such as a clean film canister.
• If your medication needs to be refrigerated, and you do not have a fridge available (for example, if you are working outside or on the road all day), try using a cooler with an ice pack. An ordinary cooler found at hardware or sporting goods stores will do.

•Consult your doctor for further instructions and also read the package insert and/or patient product information sheet that comes with your prescription.