• A particular type of acute myeloid leukaemia called acute promyelocytic leukaemia (M3).
• This medicine is used to induce remission in this particular type of leukaemia. It is used alongside chemotherapy to reduce the risk of relapse and improve survival. It can be used for people who have not yet had any treatment for their leukaemia, as well as for people whose leukaemia has not responded to chemotherapy or has come back (relapsed) after chemotherapy.
• Chemotherapy may be given at the same time as this medicine, or immediately after remission is induced.

• Tretinoin capsules are usually taken twice a day. The number of capsules to take and how long for will vary from person to person. It is important to follow the instructions given by your doctor.
• The capsules should be swallowed whole with a drink of water. They should preferably be taken with or shortly after a meal.
• If you forget to take a dose, take it as soon as you remember and tell your doctor immediately. Do not take a double dose to make up for a forgotten dose.
• Your doctor will usually want you to take this medicine until there is no sign of your leukaemia (you are in remission) or for a maximum of 90 days.
• Chemotherapy may be started during treatment with this medicine, or immediately after you stop taking it.

• You must not take vitamin A supplements (including multivitamins or fish oil supplements that contain vitamin A) while you are taking this medicine.
• This medicine may cause birth defects if used during pregnancy and for this reason you must use an effective method of contraception to avoid getting pregnant during treatment. The mini-pill is not considered an effective enough method. Contraception should preferably be started one month before you start treatment. You should continue to use contraception to prevent pregnancy during treatment and for at least one month after treatment with this medicine is stopped. Consult your doctor immediately if you think you could be pregnant during treatment.
• You will need to have regular blood tests during your treatment so that your doctor can monitor your blood cells, blood clotting, blood lipids, calcium levels and liver function.
• Retinoic acid syndrome, often associated with very high levels of blood cells called leucocytes, is a very common side effect of this medicine. You should contact your doctor immediately if you experience possible symptoms of this syndrome while taking this medicine. These include a high temperature (fever), shortness of breath, difficulty breathing, coughing, dizziness, chest pain, abdominal pain, sudden weight gain or swelling. These side effects may mean you need additional treatments.
• There is a risk of blood clots in the blood vessels during the first month of treatment with this medicine. You should let your doctor or nurse know if you get any redness, swelling or pain in your legs, chest pain, dizziness or breathlessness.

• Decreased kidney function.
• Decreased liver function.

• People who are allergic to tretinoin or other retinoid medicines. These include acitretin and tazarotene.
• People who are allergic to peanuts or soya (Tretinoin capsules contain soya bean oil).
• Rare hereditary problems of fructose intolerance (Tretinoin capsules contain sorbitol).
• Pregnancy.
• Breastfeeding. This medicine should not be used if you are allergic to one or any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy. If you feel you have experienced an allergic reaction, stop using this medicine and inform your doctor or pharmacist immediately.

•Certain medicines should not be used during pregnancy or breastfeeding. However, other medicines may be safely used in pregnancy or breastfeeding providing the benefits to the mother outweigh the risks to the unborn baby. Always inform your doctor if you are pregnant or planning a pregnancy, before using any medicine.
• This medicine should not be used during pregnancy as it causes birth defects. Your doctor may want you to have a pregnancy test before starting treatment and every month throughout treatment.
• Women who could get pregnant must use an effective method of contraception to prevent pregnancy during treatment. The mini-pill is not considered an effective enough method. Contraception should preferably be started one month before you start treatment. You should continue to use contraception to prevent pregnancy during treatment and for at least one month after treatment with this medicine is stopped. Consult your doctor immediately if you think you could be pregnant during treatment.
• This medicine may pass into breast milk. Mothers who need treatment with this medicine should not breastfeed. Seek medical advice from your doctor.

•Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Just because a side effect is stated here, it does not mean that all people using this medicine will experience that or any side effect.
• Retinoic acid syndrome. See the warning section above.
• Increased white blood cell count (hyperleukocytosis).
• Feeling generally unwell.
• Shivering.
• Decreased appetite.
• Disturbances of the gut such as diarrhoea, constipation, nausea, vomiting or abdominal pain.
• Anxiety or depression.
• Difficulty sleeping (insomnia).
• Confusion.
• Headache.
• Raised pressure inside the skull. tell your doctor if you are getting severe headaches while taking this medicine.
• Dizziness.
• Flushing.
• Pins and needles sensations.
• Problems with hearing or sight.
• Irregular heartbeat.
• Chest pain.
• Beathing problems such as slow, shallow breathing or asthma attack.
• Dry nose and mouth.
• Skin reactions such as rash, itching, hair loss, sweating.
• Bone pain.
• Raised levels of fats called cholesterol and triglycerides in the blood.
• Frequency unknown
• Raised level of calcium in the blood (hypercalcaemia).
• Increased levels of blood cells called platelets in the blood.
• Inflammation of the blood vessels (vasculitis).
• Blood clot in a blood vessel (thrombosis). See warning section above.
• Stroke or heart attack as a result of a blood clot.
• Inflammation of the muscles (myositis).
• Genital ulcers.
• Kidney problems.

•It is important to tell your doctor or pharmacist what medicines you are already taking, including those bought without a prescription and herbal medicines, before you start treatment with this medicine. Similarly, check with your doctor or pharmacist before taking any new medicines while taking this one, to make sure that the combination is safe. Tetracycline-type antibiotics, eg minocycline, doxycycline, tetracycline, must not be used in combination with this medicine, because the combination may increase the risk of a condition where there is raised pressure inside the skull (benign intracranial hypertension). You should not take vitamin supplements that contain vitamin A while you are taking this medicine, because this may result in a condition similar to vitamin A overdose. (Bear in mind that vitamin A may be found in multivitamin and fish oil supplements.) There is an increased risk of getting a blood clot in the blood vessels if anti-fibrinolytic medicines such as tranexamic acid or aprotinin are used in combination with this medicine. The following medicines may reduce the breakdown of this medicine by the liver and could increase the chance of side effects:
• fluconazole (multiple dose treatments)
• ketoconazole
• voriconazole.

•Read the package insert and/or patient product information sheet that comes with your prescription.
• Most medications should be stored in a dry place away from heat and humidity.
• Some medications also have special instructions for storage. Check for special instructions on your prescription label.
• If your medication needs to be protected from light, it should be stored in a container that filters out light, such as a clean film canister.
• If your medication needs to be refrigerated, and you do not have a fridge available (for example, if you are working outside or on the road all day), try using a cooler with an ice pack. An ordinary cooler found at hardware or sporting goods stores will do.

•Consult your doctor for further instructions and also read the package insert and/or patient product information sheet that comes with your prescription.

• Preventing and treating symptoms of seasonal nasal allergies (seasonal allergic rhinitis) such as hay fever in adults and children aged six years and over.
• Preventing and treating symptoms of nasal allergies that occur throughout the year (perennial allergic rhinitis), for example due to pet allergies or dust mite allergies, in adults and children aged six years and over.
• Nasal polyps in adults aged 18 years and over.

• Follow the instructions provided with the nasal spray. You should shake the bottle gently before use.
• Before you use the nasal spray for the first time it needs to be primed by pumping it into the air 10 times until a fine mist is produced. Hold the bottle upright and away from you while you are doing this. If the nasal spray hasn'’t been used for 14 days or more you should reprime the spray by pumping it twice into the air before using it again.
• Follow this link for general instructions on how to use a nasal spray.
• For allergies, you should preferably start using this nasal spray a few days before you expect to come into contact with the allergen (your doctor may suggest you start treatment two to four weeks before the pollen season if you suffer from very severe hay fever) and continue using it regularly all the time you are still exposed to the thing you are allergic to. Follow the instructions given by your doctor.
• To treat allergies such as hay fever, adults and children aged 12 years and over should use two sprays in each nostril once a day. Once your symptoms are under control you may be able to reduce your dose to one spray in each nostril once a day. If your symptoms are not controlled you should see your doctor, who may ask you to use the maximum dose of four sprays in each nostril once a day, and then reduce to two sprays in each nostril once a day once the symptoms have improved. You should always use the lowest dose necessary to relieve your symptoms. Do not use more than your doctor has prescribed.
• To treat allergies such as hay fever in children aged 6 to 11 years, the usual dose is one spray in each nostril once a day. Do not use more than your doctor has prescribed.
• For the treatment of nasal polyps, adults aged 18 years and over should use two sprays in each nostril once a day. If your symptoms are not improved after five to six weeks of treatment at this dose you should see your doctor, who may ask you to use the maximum dose of two sprays in each nostril twice a day. Once symptoms are under control, your doctor should ask you to reduce your dose to the lowest amount where symptoms are still controlled. If your symptoms don't improve on the maximum dose you may need a different treatment. Follow the instructions given by your doctor.
• If you forget to use your nasal spray use it as soon as you remember, unless it is nearly time for your next dose. In this case just leave out the forgotten dose and take the next dose as normal. Don'’t use a double dose to make up for a missed dose.

• This medicine is only intended for use in the nose and must not be taken by mouth.
• Take care to avoid getting the spray in your eyes.
• The plastic nozzle of your nasal spray should be cleaned at least once a week, or more frequently if the spray doesn't work because it has become blocked. Follow the printed instructions supplied with the spray. Never try to unblock the nozzle or enlarge the tiny spray hole with a pin or other sharp object, because this will destroy the spray mechanism.
• Any remaining spray must be discarded two months after you first open the bottle, because it may be contaminated with dirt or bacteria. Do not transfer any remaining suspension to another bottle. You may find it helpful to write the date of first opening on the bottle so you know when to throw it away. Dispose of carefully, preferably by returning it to a pharmacy.
• When taken in high doses for long periods of time, corticosteroids have the potential to cause glaucoma, cataracts, slowed growth in children and adolescents, and to decrease the functioning of the adrenal glands (glands that produce natural steroid hormones). These side effects on other areas of the body are called systemic side effects and are extremely unlikely to occur with this nasal spray, because the amount of mometasone absorbed into the bloodstream from the nose is very low. However, as a precaution, your doctor will prescribe the lowest effective dose needed to control your symptoms. You should not exceed this prescribed dose. If your child is using this nasal spray for long periods of time your doctor may want to monitor their height to make sure their growth is not being affected. For further information discuss this with your doctor.

• People with an infection in the nasal passages or sinuses (the infection should be treated).
• People who have recently had nasal surgery or an injury to the nose (this medicine should not be used until the nose has healed).
• People with tuberculosis affecting the lungs.

• This medicine is not recommended for treating allergies in children under six years of age, or for treating nasal polyps in children under 18 years of age. This medicine should not be used if you are allergic to any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy. If you feel you have experienced an allergic reaction, stop using this medicine and inform your doctor or pharmacist immediately.

•Certain medicines should not be used during pregnancy or breastfeeding. However, other medicines may be safely used in pregnancy or breastfeeding providing the benefits to the mother outweigh the risks to the unborn baby. Always inform your doctor if you are pregnant or planning a pregnancy, before using any medicine.
• The safety of this medicine for use during pregnancy has not been established. Only minimal amounts of the medicine pass into the bloodstream after using the nasal spray. However, the manufacturer states that this medicine is not recommended for use in pregnancy unless the potential benefit to the mother outweighs any risk to the developing baby. Seek medical advice from your doctor.
• It is not known if this medicine passes into breast milk. The manufacturer states that it is not recommended for use during breastfeeding unless the potential benefit to the mother outweighs any risk to the nursing infant. Seek medical advice from your doctor.

•Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Just because a side effect is stated here, it does not mean that all people using this medicine will experience that or any side effect.
• Headache.
• Nosebleeds.
• Inflammation and soreness of the throat (pharyngitis).
• Irritation or burning sensation in the nose.
• Ulceration in the nose.
• Perforation of the nasal septum.
• Raised pressure in the eye or glaucoma.
• Cataract.
• Narrowing of the airways and shortness of breath (bronchospasm - an allergic reaction).
• Smell or taste disturbances.
• Allergic reactions such swelling of the lips, throat and tongue (angioedema) or anaphylactic shock.
• Side effects similar to those associated with corticosteroids taken by mouth may occur if this medicine is absorbed into the bloodstream. This is unlikely unless the medicine is used at high doses for prolonged periods of time. See the warning section above or talk to your doctor or pharmacist for more details. The side effects listed above may not include all of the side effects reported by the medicine's manufacturer. For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist.

•Mometasone is not known to affect other medicines when administered into the nose as a nasal spray. However, if you are taking any other medicines, including those bought without a prescription and herbal medicines, you should tell your doctor or pharmacist before you start treatment with this medicine. This is particularly important if you are or have recently been using any other medicines that contain corticosteroids, for example tablets, injections, eye or nose drops, creams, asthma inhalers, or other similar nasal sprays. This is because there may be an increased chance of adverse effects if you are using more than one type of steroid medication and your doctor may want to monitor you more closely.

•Read the package insert and/or patient product information sheet that comes with your prescription.
• Most medications should be stored in a dry place away from heat and humidity.
• Some medications also have special instructions for storage. Check for special instructions on your prescription label.
• If your medication needs to be protected from light, it should be stored in a container that filters out light, such as a clean film canister.
• If your medication needs to be refrigerated, and you do not have a fridge available (for example, if you are working outside or on the road all day), try using a cooler with an ice pack. An ordinary cooler found at hardware or sporting goods stores will do.

•Consult your doctor for further instructions and also read the package insert and/or patient product information sheet that comes with your prescription.

• Hydroquinone is used to gradually lighten the  skin that has become dark or skin that has developed dark patches due to many skin problems. These include melasma-skin darkening due to exposure to sunlight especially in women using oral contraceptives (birth control pills), during pregnancy, or on hormone replacement therapy during menopause (hormonal drugs to replace deficient hormones in the body), freckles (clusters of dark spots on cheeks, nose, arms, and upper shoulders that start appearing at a very young age) and solar lentigines (also called ‘age spots’ are brown or black spots on the face, hands, shoulders and arms-areas that get exposed to sun light).

• Do not take this drug by mouth. Use on your skin only. Keep out of your mouth, nose, and eyes (may burn). Wash your hands before and after use. Clean affected part before use. Make sure to dry well. Put a thin layer on the affected skin and rub in gently. Practice good skin care and avoid the sun.

• If you have an allergy to hydroquinone or any other part of this drug. If you have a sulfite allergy, talk with your doctor. Tell your doctor if you are allergic to any drugs. Make sure to tell about the allergy and what signs you had. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs. If you are sunburned.

• Please use hydroquinone products carefully. Its skin bleaching action may produce unwanted cosmetic effects if not used as directed. Use of sunscreen is a must while using hydroquinone. Avoid unnecessary sun exposures and cover the treated areas with clothing. Even minimal exposure to sunlight can reverse the bleaching effect of hydroquinone. Discontinue use and contact your doctor immediately if you develop allergic skin reaction or notice blue-black darkening of skin upon use of hydroquinone. Hydroquinone creams are meant for external use on the skin only. Immediately wash-off with water, if the cream gets into your eyes, nose, mouth, or on your lips. Do not use hydroquinone creams on broken, irritated or injured skin. Do not use hydroquinone creams with other creams that contain peroxides (hydrogen peroxide/benzoyl peroxide). This may produce a dark stain on your skin which can be removed by stopping the use of peroxides and washing with soap and water. Do not use hydroquinone creams with other creams that contain resorcinol, phenol, or salicylic acid unless advised by your doctor. Please check, if the hydroquinone cream contains sulfites. Such products may trigger allergic reactions in individuals with asthma.

• Patients with a history of severe allergic reaction to hydroquinone or any other ingredient in the medicine.

•Category C : Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

•Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Just because a side effect is stated here, it does not mean that all people using this medicine will experience that or any side effect.
• Skin irritation, eg itching, burning, stinging.
• Thinning of the skin.
• Changes in skin pigmentation.
• Stretch marks (striae).
• Groupings of fine blood vessels becoming prominent under the skin (telangiectasia).
• Excessive hair growth (hypertrichosis). Prolonged use of this medicine on extensive areas of skin, broken or raw skin, skin folds or underneath airtight dressings may on rare occasions result in enough corticosteroid being absorbed to have side effects on other parts of the body, for example a decrease in the production of natural hormones by the adrenal glands - see warning section above. The side effects listed above may not include all of the side effects reported by the medicine's manufacturer. For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist.

•It is important to tell your doctor or pharmacist what medicines you are already taking, including those bought without a prescription and herbal medicines, before you start treatment with this medicine. Similarly, check with your doctor or pharmacist before taking any new medicines while being treated with this one, to make sure that the combination is safe. Abiraterone may increase the levels of the following medicines in the blood. If you are taking any of these your doctor may have to reduce your dosage:
• codeine
• desipramine
• flecainide
• haloperidol
• metoprolol
• propafenone
• propranolol
• risperidone
• oxycodone
• tramadol
• venlafaxine. The following medicines could affect the level of abiraterone in the blood and so should be avoided where possible while you are having treatment with this medicine:
• atazanavir
• azole antifungals such as ketoconazole, itraconazole
• carbamazepine
• clarithromycin
• indinavir
• nefazodone
• nelfinavir
• phenobarbital
• phenytoin
• rifabutin
• rifampicin
• rifapentine
• ritonavir
• saquinavir
• telithromycin
• voriconazole.

•Read the package insert and/or patient product information sheet that comes with your prescription.
• Most medications should be stored in a dry place away from heat and humidity.
• Some medications also have special instructions for storage. Check for special instructions on your prescription label.
• If your medication needs to be protected from light, it should be stored in a container that filters out light, such as a clean film canister.
• If your medication needs to be refrigerated, and you do not have a fridge available (for example, if you are working outside or on the road all day), try using a cooler with an ice pack. An ordinary cooler found at hardware or sporting goods stores will do.

•Consult your doctor for further instructions and also read the package insert and/or patient product information sheet that comes with your prescription.